解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Laryngeal squamous cell carcinoma is a frequent and significant cause of morbidity and mortality. Here we explore the biological basis of this aggressive tumour, and identify two cell-cell adhesion genes as recurrently mutated in this malignancy. We first perform exome sequencing of four laryngeal carcinomas and their...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3531
更新日期:2013-01-01 00:00:00
abstract::Molecular shape recognition for larger guest molecules (typically over 1 nm) is a difficult task because it requires cooperativity within a wide three-dimensional nanospace coincidentally probing every molecular aspect (size, outline shape, flexibility and specific groups). Although the intelligent functions of protei...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3581
更新日期:2013-01-01 00:00:00
abstract::In vitro fabrication of functional vascularized three-dimensional tissues has been a long-standing objective in the field of tissue engineering. Here we report a technique to engineer cardiac tissues with perfusable blood vessels in vitro. Using resected tissue with a connectable artery and vein as a vascular bed, we ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2406
更新日期:2013-01-01 00:00:00
abstract::Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2425
更新日期:2013-01-01 00:00:00
abstract::The sensitivity of quantum magnetometer is challenged by control errors and, especially in the solid state, by their short coherence times. Refocusing techniques can overcome these limitations and improve the sensitivity to periodic fields, but they come at the cost of reduced bandwidth and cannot be applied to sense ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2375
更新日期:2013-01-01 00:00:00
abstract::Since the formulation of the geometric phase by Berry, its relevance has been demonstrated in a large variety of physical systems. However, a geometric phase of the most fundamental spin-1/2 system, the electron spin, has not been observed directly and controlled independently from dynamical phases. Here we report exp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3526
更新日期:2013-01-01 00:00:00
abstract::Within all physical disciplines, it is accepted that wave transport is predetermined by the existence of disorder. In this vein, it is known that ballistic transport is possible only when a structure is ordered, and that disorder is crucial for diffusion or (Anderson-)localization to occur. As this commonly accepted p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3533
更新日期:2013-01-01 00:00:00
abstract::Erythropoietin regulates erythropoiesis in a hypoxia-inducible manner. Here we generate inherited super-anaemic mice (ISAM) as a mouse model of adult-onset anaemia caused by erythropoietin deficiency. ISAM express erythropoietin in the liver but lack erythropoietin production in the kidney. Around weaning age, when th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2950
更新日期:2013-01-01 00:00:00
abstract::Viruses cause 10-15% of all human cancers. Massively parallel sequencing has recently proved effective for uncovering novel viruses and virus-tumour associations, but this approach has not yet been applied to comprehensive patient cohorts. Here we screen a diverse landscape of human cancer, encompassing 4,433 tumours ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3513
更新日期:2013-01-01 00:00:00
abstract::Chemical functionalization is one of the most powerful and widely used strategies to control the properties of nanomaterials, particularly in the field of graphene. However, the ill-defined structure of the present functionalized graphene inhibits atomically precise structural characterization and structure-correlated...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3646
更新日期:2013-01-01 00:00:00
abstract::Various viruses enter host cells via endocytosis, but the molecular mechanisms underlying the specific internalization pathways remain unclear. Here we show that influenza A viruses (IAVs) enter cells via redundant pathways of clathrin-mediated and clathrin-independent endocytosis, with intracellular Ca(2+) having a c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3763
更新日期:2013-01-01 00:00:00
abstract::Neurofilaments are intermediate filaments assembled from the subunits neurofilament-low, neurofilament-medium and neurofilament-high. In axons, parallel neurofilaments form a nematic liquid-crystal hydrogel with network structure arising from interactions between the neurofilaments' C-terminal sidearms. Here we report...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3224
更新日期:2013-01-01 00:00:00
abstract::Metal-organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be further enhanced by encapsulating functional species, such as luminescent guest molecules, within the frameworks. Al...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3717
更新日期:2013-01-01 00:00:00
abstract::Gate operations in a quantum information processor are generally realized by tailoring specific periods of free and driven evolution of a quantum system. Unwanted environmental noise, which may in principle be distinct during these two periods, acts to decohere the system and increase the gate error rate. Although the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3337
更新日期:2013-01-01 00:00:00
abstract::The low-energy electronic excitations in graphene are described by massless Dirac fermions that have a linear dispersion relation. Taking advantage of this 'optics-like' electron dynamics, generic optical elements like lenses and wave guides have been proposed for electrons in graphene. Tuning of these elements relies...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3342
更新日期:2013-01-01 00:00:00
abstract::Gluconeogenesis is a fundamental feature of hepatocytes. Whether this gluconeogenic activity is also present in malignant hepatocytes remains unexplored. A better understanding of this biological process may lead to novel therapeutic strategies. Here we show that gluconeogenesis is not present in mouse or human malign...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3508
更新日期:2013-01-01 00:00:00
abstract::Over the last century the North Anatolian Fault Zone in Turkey has produced a remarkable sequence of large earthquakes. These events have now left an earthquake gap south of Istanbul and beneath the Marmara Sea, a gap that has not been filled for 250 years. Here we investigate the nature of the eastern end of this gap...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2999
更新日期:2013-01-01 00:00:00
abstract::Pathogen-associated molecular patterns (PAMPs) are known to be fundamental in instigating immune responses, but their role in influencing these responses beyond their initiation is less well understood. Here, using the protozoan parasite Trypanosoma cruzi, which is deficient in strong PAMPs, we demonstrate a requireme...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3616
更新日期:2013-01-01 00:00:00
abstract::Schizophrenia and bipolar disorder are major psychiatric disorders with high heritability and overlapping genetic variance. Here we perform a genome-wide association study in an ethnically homogeneous cohort of 904 schizophrenia cases and 1,640 controls drawn from the Ashkenazi Jewish population. We identify a novel g...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3739
更新日期:2013-01-01 00:00:00
abstract::Neurons can activate pathways that destroy the whole cell via apoptosis or selectively degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and caspases. Here we demonstrate that despite this overlap, the pathways mediating axon degeneration during apoptosis versus axon pruning are dist...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2910
更新日期:2013-01-01 00:00:00
abstract::Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin using a high-throughput compound library screening and show that it induces the transcriptional activity of the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2924
更新日期:2013-01-01 00:00:00
abstract::Heparin-like oligosaccharides mediate numerous important biological interactions, of which many are implicated in various diseases. Synthetic improvements are central to the development of such oligosaccharides as therapeutics and, in addition, there are no methods to elucidate the pharmacokinetics of structurally def...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3016
更新日期:2013-01-01 00:00:00
abstract::The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of proliferation of peripherally-derived inflammatory macrophages under physiological conditions. Here we show that proliferation of both bone marrow-derived infl...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2877
更新日期:2013-01-01 00:00:00
abstract::Erythropoietin (Epo) supports both primitive erythropoiesis in the yolk sac and definitive erythropoiesis in the fetal liver and bone marrow. Although definitive erythropoiesis requires kidney- and liver-secreted Epo, it is unclear which cells produce Epo for primitive erythropoiesis. Here we find neural Epo-producing...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3902
更新日期:2013-01-01 00:00:00
abstract::Biological tissues have the remarkable ability to remodel and repair in response to disease, injury and mechanical stresses. Synthetic materials lack the complexity of biological tissues, and man-made materials that respond to external stresses through a permanent increase in stiffness are uncommon. Here we report tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2772
更新日期:2013-01-01 00:00:00
abstract::Development of promising battery systems is being intensified to fulfil the needs of long-driving-ranged electric vehicles. The successful candidates for new generation batteries should have higher energy densities than those of currently used batteries and reasonable rechargeability. Here we report that aqueous lithi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2907
更新日期:2013-01-01 00:00:00
abstract::Manipulation of nonlinear waves in artificial periodic structures leads to spectacular spatial features, such as generation of gap solitons or onset of the Mott insulator phase transition. Cavity exciton-polaritons are strongly interacting quasiparticles offering large possibilities for potential optical technologies....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2760
更新日期:2013-01-01 00:00:00
abstract::Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2906
更新日期:2013-01-01 00:00:00
abstract::Efficient charge separation is of crucial importance for the improvement of photocatalytic activity for solar hydrogen evolution. Here we report efficient photo-generated charge separation by twin-induced one-dimensional homojunctions with type-II staggered band alignment, using a ternary chalcogenate, i.e. Cd0.5Zn0.5...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3278
更新日期:2013-01-01 00:00:00
abstract::Cryptochrome (Cry) 1 and Cry2 are regarded as critical components for circadian rhythm generation in mammals. Nevertheless, cultured suprachiasmatic nucleus (SCN) of neonatal Cry double deficient (Cry1(-/-)/Cry2(-/-)) mice exhibit circadian rhythms that damp out in several cycles. Here, by combining bioluminescence im...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2670
更新日期:2013-01-01 00:00:00
abstract::Increased vascular permeability contributes to many diseases, including acute respiratory distress syndrome, cancer and inflammation. Most past work on vascular barrier function has focused on soluble regulators, such as tumour-necrosis factor-α. Here we show that lung vascular permeability is controlled mechanically ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2774
更新日期:2013-01-01 00:00:00
abstract::During homologous recombination, eukaryotic RecA homologue Rad51 assembles into a nucleoprotein filament on single-stranded DNA to catalyse homologous pairing and DNA-strand exchange with a homologous template. Rad51 nucleoprotein filaments are highly dynamic and regulated via the coordinated actions of various access...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2678
更新日期:2013-01-01 00:00:00
abstract::Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue. Here we show that microRNA 155 is enriched in brown adipose tissue and is highly expressed in proliferating brown preadipocytes but declines after induction of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2742
更新日期:2013-01-01 00:00:00
abstract::Among calcareous nannofossils, important primary producers in Jurassic and Cretaceous oceans, nannoconids were carbonate rock-forming organisms. During the late Barremian and early Aptian (~126 to 122 million years ago), nannoconids went through a crisis culminating during the Oceanic Anoxic Event 1a. Here we present ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2698
更新日期:2013-01-01 00:00:00
abstract::Advances in chemistry and massively parallel detection underlie DNA-sequencing platforms that are poised for application in personalized medicine. In stark contrast, systematic generation of protein-level data lags well behind genomics in virtually every aspect: depth of coverage, throughput, ease of sample preparatio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3171
更新日期:2013-01-01 00:00:00
abstract::Although environmental selection and spatial separation have been shown to shape the distribution and abundance of marine microorganisms, the effects of advection (physical transport) have not been directly tested. Here we examine 25 samples covering all major water masses of the Southern Ocean to determine the effect...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3457
更新日期:2013-01-01 00:00:00
abstract::Optogenetics has emerged as an alternative method for electrical control of the heart, where illumination is used to elicit a bioelectric response in tissue modified to express photosensitive proteins (opsins). This technology promises to enable evocation of spatiotemporally precise responses in targeted cells or tiss...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3370
更新日期:2013-01-01 00:00:00
abstract::Black silicon is a synthetic nanomaterial that contains high aspect ratio nanoprotrusions on its surface, produced through a simple reactive-ion etching technique for use in photovoltaic applications. Surfaces with high aspect-ratio nanofeatures are also common in the natural world, for example, the wings of the drago...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3838
更新日期:2013-01-01 00:00:00
abstract::Syngnathid fish (seahorses, pipefish and sea dragons) are slow swimmers yet capture evasive prey (copepods) using a technique known as the 'pivot' feeding, which involves rapid movement to overcome prey escape capabilities. However, this feeding mode functions only at short range and requires approaching very closely ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3840
更新日期:2013-01-01 00:00:00
abstract::Oriented assemblies of functional nanoparticles, with the aid of external physical and chemical driving forces, have been prepared on two-dimensional solid substrates. It is challengeable, however, to achieve three-dimensional assembly directly in solution, owing to thermal fluctuations and free diffusion. Here we des...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3182
更新日期:2013-01-01 00:00:00